Leukocyte Recruitment after Brain Injury Signaling through MyD88 Regulates
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A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide.
To study the mechanisms involved in leukocyte recruitment induced by local bacterial infection within the CNS, we used intravital microscopy to visualize the interaction between leukocytes and the microvasculature in the brain. First, we showed that intracerebroventricular injection of LPS could cause significant rolling and adhesion of leukocytes in the brain postcapillary venules of wild-type...
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تاریخ انتشار 2008